The UKB cohort has been previously-described27. Of note, genotypes were imputed using a larger number of individuals from the UK10K combined with 1000 Genomes Project as a reference panel (n=6,285). SBP measures were taken from manual (variable 93.0-2.0-1) and automatic readings (4080.0-2.0-1), as were DBP (94.0-2.0-1 and 4079.0-2.0-1, respectively). Age was reported as the age at measurement (34.0.0). Anti-hypertensive use was assessed by self-report (6153.0-1.0 and 6177.0-2.0), and BPs were corrected as in GERA. BMI was calculated from measured weight and height (21001.0.0). Sex was determined genetically (22001.0.0). Analysis was done as in GERA, a meta-analysis of each self-reported race/ethnicity group (21000.0-2.0): we identified 145,341 individuals who reported any white race/ethnicity group and with global ancestry PC1≤50 and PC2≤50, where global PC1 and PC2 were calculated from the entire cohort (22009.0.1-2), including 2,274 South Asians, 2,029 African British, 1,979 mixed/other, and 458 East Asians, totaling 152,081 individuals. Ancestry PCs within whites were calculated using 50,000 random white individuals with the remaining subjects projected, which has been shown to work well45, and then within each other group. We analyzed 35,893,267, 12,078,001,
