and 458 East Asians, totaling 152,081 individuals. Ancestry PCs within whites were calculated using 50,000 random white individuals with the remaining subjects projected, which has been shown to work well45, and then within each other group. We analyzed 35,893,267, 12,078,001, 19,866,667, 15,820,020, and 7,298,789 SNPs with rinfo2≥0.3 and MAF≥0.0001, 0.005, 0.005, 0.005, and 0.025, in whites, South Asians, African-European, mixed/other, and East Asians, respectively (42,521,712 unique SNPs).