We calculated the rate of phenotypic abnormalities in all mouse lines with reduced expression of genes identified in our prediXcan analysis (“SCZ-associated mouse lines”). We compared these to (1) the ‘baseline’ rate of phenotypic abnormalities across all 10,288 mouse lines; and (2) the rate of abnormalities in mouse lines associated with other disorders. To do this, we downloaded all publicly-available whole-blood-derived S-PrediXcan results (as of March 2018, see URLs). In total, we obtained data for 1,907 genes reaching p < 5 × 10−6, across 65 studies. We calculated rates of phenotypic abnormalities for each of these 65 studies.
