Another significant locus, HSD17B11, encoding hydroxysteroid 17-beta dehydrogenase 11, shares some biological features with CHRH1. Its protein product functions in steroid hormone metabolism and synthesis. Two of the eight GWS loci (one also significant on the gene level) thus fit closely with our current understanding of stress response and its relationship to PTSD. HSD17B11 was replicated in the UKB sample.
