of the differences not just in local LD but in larger-scale genomic structure (Figure S6). CRHR1 also emerged as one of top genes in the gene-based genomewide analysis using MAGMA; and it was also replicated in the UKB cohort. CRHR1 is involved in steroid signaling and response. This is a stress-response pathway long believed to be important in PTSD pathophysiology, and there has been considerable prior interest in CRHR114,15 for PTSD and related phenotypes (notably neuroticism,16 with which we find PTSD to be genetically correlated). The two lines of evidence presented herein – SNP-based and gene-based – together with the prior biological support, make a strong case for the validity and importance of this discovery.
