Ethanol-derived acetate may also be converted to citrate/isocitrate, which could be transported out of the mitochondria to the cytoplasm and contribute carbons to de novo lipogenesis (Lustig, 2013). Ethanol metabolism in human brain has been documented to occur with the formation of fatty acid ethyl esters. These neutral lipids can disorder membranes and interrupt mitochondrial functions (Bora and Lange, 1993). The de novo synthesized lipids may also accumulate inside neurons as oil droplets, rendering them as lipid-laden and is associated with amyloid-β peptide signals in Alzheimer’s disease patients (Gomez-Ramos and Asuncion Moran, 2007).
