Chunk #43 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Reliability of pedigree structure reports was assessed by comparing family structure information provided by the proband and another first degree relative informant from these 79 families. Parents agreed (completely) with 100% of the proband’s pedigree assignments, while sibs agreed (completely) with 70% of all possible pedigrees. Disagreements were largely due to differential reporting of half vs full siblings.