Chunk #44 — II. Samples for genome studies of human addiction vulnerabilities and related phenotypes (Figure 2)

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Molecular genetics of addiction and related heritable phenotypes: genome-wide association approaches identify "connectivity constellation" and drug target genes with pleiotropic effects.

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Reliability of information about drug histories was assessed by comparing drug use survey (DUS) and family history/research diagnostic criteria (FH/RDC) estimates of drug use by the proband with FH/RDC estimations from first-degree relatives. 73% of parental evaluations agreed (completely) with the probands’ evaluations of all pedigree members’ status with respect to all abused substances. 81% of sib evaluations were concordant (completely) with the proband’s evaluations of his/her own drug use. Differences were most prominent in both cases due to family member underestimation and/or under-reporting of offspring/sib drug use.