We next used cell-type specific databases to ask which treatments might disproportionately affect genes enriched in different types of cells. The clearest finding is that LPS treatment increased expression of genes enriched in PFC microglia and liver Kupffer cells (Figure 3). The alcohol treatments produced modest changes in cell-type specific expression in PFC (Figure 3A). It should be noted that these analyses are based on all genes with cell-type enrichment whereas the data in Figure 2 are derived from all differentially expressed genes, thus the overlaps seen in Figure 2 (e.g., CI and LPS) are not prominent in the cell-type analysis.
