Sample 1 consists of individuals for whom the data was released in May 2015 (N = 110,328; Supplementary Table 1), whereas sample 2 consists of all individuals that were added in the 2nd release (July 2017; N = 270,178; Supplementary Table 2). Written informed consent was obtained from all participants and the UK Biobank received ethical approval from the National Research Ethics Service Committee North West–Haydock (ref. 11/NW/0382). The current study was conducted under UK Biobank application number 16406.
