In addition, findings with the selected HAP and LAP mouse lines did not support the hypothesis, with the observation that these lines did not differ in initial sensitivity or the development of tolerance to alcohol-induced motor ataxia (Grahame et al. 2000). Nor was tolerance in the grid test of alcohol-induced motor impairment correlated with preference or drinking across the extensive set of BXD RI strains (Phillips et al. 1996).
