In discussions appearing in the literature, one rodent assay appears frequently and is often asserted to model human LR—the duration of the LORR after an anesthetic dose of alcohol. Why this would be considered to be a reasonable surrogate for human body sway is puzzling. While there are strong genetic contributions to LORR, and mouse and rat lines have been bred to differ markedly in LORR to high dose alcohol (McClearn, Kakihana 1981;Deitrich 1993), the available evidence shows that the genes influencing LORR sensitivity in rodents do not overlap substantially with those affecting other measures of physical intoxication across inbred strains (Crabbe et al. 2005) or in the BXD RI series (Browman, Crabbe 2000). Nor did LORR appear to be genetically correlated with alcohol drinking or withdrawal in rodents such as the WSP and WSR lines (Crabbe, Kosobud 1986).
