Chunk #14 — THE GENETIC BASIS OF VULNERABILITY TO ALCOHOLISM — The Neurobiology of Addiction: Dopamine Reward Circuitry and Interacting Stress Response Systems
The transition to addiction involves multiple neuroadaptations and much of our understanding of these processes has so far been obtained from animal studies. However the use of microarrays and advances in next-generation RNA-sequencing (RNA-Seq) [35] have conferred the ability to quantify mRNA transcripts in postmortem brain and analyze expression differences between alcoholics and controls within gene networks [36–39].
