replicated this study in a south-west Californian Indian population of alcoholics and controls and observed a protective role for the ALDH1A1*2 polymorphism, whereby individuals with an ALDH1A1*2 allele reported lower rates of alcohol dependence, drank fewer drinks per session and reported a lower maximum number of drinks consumed in a 24-hour period. Conversely, the ALDH1A1*2 alleles were later reported to be associated with increased development of alcohol dependency in Indo-Trinidadians [9].
