Two other studies have reported genetic linkage in the 9q21 region with phenotypic measures of alcohol consumption in predominantly Caucasian American samples from the Framingham Heart Study (FHS). Bergen et al. [10] observed nominally significant evidence of linkage in the 9q21.11 region between three loci and a square-root-transformed 'maximum alcohol consumed in a 24-hour period' variable, MAXAPD. Stronger evidence for linkage of MAXAPD on chromosome 9 was detected by Ma et al. [11] with a maximal logarithm of the odds ratio (LOD) score of 2.27 in the region of ALDH1A1.
