Similar to stroke, psychiatric diseases including depression and schizophrenia are being increasingly viewed as network disorders involving abnormal interactions between multiple brain regions. However, unlike stroke, the regions and networks involved are not immediately obvious using routine clinical imaging. While this has lead to great interest in the potential of functional connectivity for revealing previously hidden pathology, there has been a large degree of heterogeneity in the networks of interest and results (Greicius, 2008; Fox & Greicius, 2010; Zhang & Raichle, 2010). Early neuroimaging studies suggested that one of the changes seen in depressed subjects is a relative hypoactivity of the left dorsal prefrontal cortex (Baxter et al., 1989; Martinot et al., 1990; Drevets, 2000), with a normalization of activity accompanying response to treatment (Bench et al., 1995; Mayberg et al., 2000). More recent studies using functional connectivity techniques have focused on the subgenual cingulate cortex (Mayberg et al., 2005), dorsolateral prefrontal cortex (for example see (Seminowicz et al., 2004)) and the default mode network (DMN). Reported functional connectivity abnormalities include decreased corticolimbic connectivity (especially with the dorsal anterior cingulate),
