Chunk #93 — Methods — Calculation of σg in reference set

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Exploring the phenotypic consequences of tissue specific gene expression variation inferred from GWAS summary statistics.

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The variance of predicted expression is computed using Eq. (4) which takes weights for each SNP in the prediction model and the correlation (LD) between the SNPs. The correlation is computed in a reference set such as 1000G or in the training set.