Chunk #36 — Methods — Statistical methods. — IMPACT model.

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Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements.

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We use a weighted average of ridge and lasso regularization terms in the objective function to restrict the magnitude of fit coefficients and enforce sparsity to reduce overfitting, respectively, as follows: argminβ=‖Y−Xβ‖2+12(1−α)‖β‖2+α‖β‖.