Chunk #35 — Methods — Statistical methods. — IMPACT model.

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Improving the trans-ancestry portability of polygenic risk scores by prioritizing variants in predicted cell-type-specific regulatory elements.

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We implemented our previously defined model to predict TF binding on a motif site. This model regresses the log odds of the probability (p) of a binding event on the epigenomic profile of the motif site, in a logistic regression framework over j epigenomic features as follows: log(p1−p)=β0+β1X1+β2X2+…+βjXj.