We began by testing if the entire set of 29 genes encoding members of the SWI/SNF complex was associated as a whole with a phenotype of AD in the COGA case/control sample. We found that, using a set-based analysis, the 29 genes in the SWI/SNF complex was associated with alcohol dependence at p=0.0435. We next asked which of the genes in the set of 29 contributed to this association by performing individual gene-based tests on each gene. Table 1 shows the results for individual gene-based tests. We found that SS18L1, SMARCD1, BRD7, SMARCB1 and BCL11A were all significant at p<0.05.
