The Spit for Science sample members are young, and therefore appropriate for examining the genetic contributions to an antisocial behavior phenotype that has been described as an early predictor of alcohol problems (Kuperman et al., 2001, Kessler et al., 1997, Zucker, 2008). We tested if there was an association between SWI/SNF complex members and antisocial behavior. We began by testing the set of 29 known SWI/SNF genes as a whole, and found that the set-based analysis of the SWI/SNF complex genes showed significant association with antisocial behavior in the Spit for Science sample (p=0.00026). We next used gene-based analyses to identify the members of the set that were contributing to this signal. We found that ACTB, ARID2, BCL11A, BCL11B, BCL7B, BCL7C, DPF2, and DPF3 all yielded p<0.05, contributing to the highly significant association of the set (Table 2).
