was selected in an attempt to maximize the response to alcohol on the expression of genes. All research protocols were approved by the Indiana University School of Medicine Institutional Animal Care and Use Committee and are in accordance with the guidelines of the Institutional Care and Use Committee of the National Institute on Drug Abuse, National Institutes of Health, and the Guide for the Care and Use of Laboratory Animals (Institute of Laboratory Animal Research & Council, 1996)). As previously reported (McBride et al., 2014a), adolescent male P rats had an average ethanol intake of 10 g/kg in the three 1-hr scheduled access sessions during the first week, with average intakes of 3 – 4 g/kg in each of the 3 sessions. In the second and third weeks, the P rats had an average ethanol intake of 8 g/kg in the three 1-hr sessions, with average intakes of 2.5 – 3 g/kg in each of the three 1-hr sessions.
