Twenty-one SNPs were significant after multiple test correction (p < 0.000462), using the primary 1 df logistic regression test. These 21 SNPs form five distinct r2 bins in the following genes or gene clusters: CHRNA5-CHRNA3-CHRNB4 (3 bins), CHRNB3-CHRNA6 (1 bin), and CHRND, (1 bin). Of the three bins in the CHRNA5-CHRNA3-CHRNB4 cluster, two are still correlated with each other as detailed below, leading to two distinct signals in the cluster.
