Eight of the significant SNPs are on chromosome 8 in the β3-α6 gene cluster, twelve are on chromosome 15 in or near the α5—α3—β4 cluster, and one is on chromosome 2 in CHRND. These significant results are in bold in Table II, which presents association results for all SNPs genes or gene clusters that contained at least one SNP with primary p-value ≤ 0.05. Association results for all 226 SNPs sorted by chromosome and position are in supplementary table S1, so that the coverage for every nAChR gene may be seen. To aid interpretation, the tables also include the LD bin membership of the SNPs, as described in the methods. Of the 226 SNPs, 84 are nominally significant. For the nominally significant SNPs, supplementary table S1 gives p-values for the “best model” determined as described in the methods.
