These two analyses are generally concordant, and show highly trait-specific patterns of cell-type enrichment. They also recapitulate several well-known findings. For example, the top cell type for each of the three lipid traits is liver (FDR < 0.05 for all three traits). For both type 2 diabetes and fasting glucose, the top cell type is pancreatic islets (FDR < 0.05 for fasting glucose but not type 2 diabetes). For the three psychiatric traits, the top cell type is a brain cell type and the top cell-type group is CNS (FDR < 0.05 for schizophrenia and bipolar disorder but not for anorexia). These results are concordant with the medical literature [39, 40] and with previous analysis of these GWAS datasets [9, 18, 27, 31, 41, 42].
