There are also several new insights among these results. For example, the three immunological disorders show patterns of enrichment that reflect biological differences among the three disorders. Crohn’s disease has 40 cell types with FDR < 0.05, of which 39 are immune cell types and one (colonic mucosa) is a GI cell type. On the other hand, the 39 cell types with FDR < 0.05 for ulcerative colitis include nine GI cell types in addition to 30 immune cell types, whereas all 39 cell types with FDR < 0.05 for rheumatoid arthritis are immune cell types. The top cell type for all three traits is CD4+ CD25- IL17+ PMA Ionomycin simulated Th17 primary. Th17 cells are thought to act in opposition to Treg cells, which have been shown to suppress immune activity and whose malfunction has been associated with immunological disorders [43].
