Twelve studies required medication intake supervision by a family member, friend, or a member of the clinic staff while eight did not require this supervision. In the remaining two studies, half of the subjects were supervised in one case [25] and in the other, the study medication was to be taken with methadone and was supervised only in those without take home privileges [32]. In ten of the supervised studies, the control arm was also supervised when it consisted of another medication or a placebo. In the three remaining studies, the control arm was “no disulfiram” and thus no supervision was possible [25], [31], [42].
