The DNA and RNA tubes were shipped on dry ice to ISMMS as homogenized tissue in trizol for RNA extraction and thinly sliced tissue for DNA extraction. Specimens from Pitt were provided as matched case/control pairs. These were perfectly matched for sex, and as closely as possible for age (73% of pairs were matched within 5 years, and 95% within 10 years) and race (71% of pairs were matched for race). Members of a pair were always processed together for RNA-seq. Tissue for 10 of the Pitt controls was extracted in duplicate, once as part of a SCZ pair and once as part of a bipolar pair.
