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Chunk #28 — Methods — Polygenic scores — Target samples.

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Multivariate genetic of 2.2 million individuals demonstrate genetic influences on substance use disorders operate via behavioral disinhibition and substance-specific risk.
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We calculated polygenic scores among EUR individuals from the Collaborative Study on the Genetics of Alcoholism (COGA; N = 7,530) and All of Us (Nmax = 77,442).