The Collaborative Study on the Genetics of Alcoholism is a large, multi-site, family-based study incorporating multiple generations with the goal of studying etiological influences on alcohol use disorders (AUDs)39. Individuals in treatment for alcohol use disorder and their families were recruited into the study along with a smaller number of community-based comparison families beginning in 1991. Data were collected over four waves, culminating in data available for those included in the initial assessment, follow-up of individuals in the first wave, a prospective wave, which focused on longitudinal assessments of youth in case and comparison families, and an ongoing wave of participants now in midlife and later life stages. The present study includes data from individuals in waves 1-3 who were of EUR ancestry and had GWAS data available.
