Although this is an outbred colony of macaques 37, to verify that our effects were attributable to CRH variation, and not to general heritability of stress responsivity, we repeated our analyses using a set of six randomly selected bi-allelic genetic markers used for genotyping in our colony. There were no effects of the other markers tested (data not shown), suggesting our results to be attributable to effects of rhCRH variation on our phenotypes of interest. -2232 C/G allele frequencies were in agreement with Hardy-Weinberg. There were two animals with the G/G genotype among these datasets, which were collapsed with G allele carriers for the purpose of this analysis. To account for non-homogeneity of variances, dependent variables were rank-transformed when appropriate. Analyses were performed using Statview 5.01 statistical software. Criterion for significance was set at P ≤ 0.05.
