In light of the previous BCHE findings from the literature, and the evidence that rs11720469 is an eQTL for BCHE, this discussion has primarily focused on BCHE. However, there are several other potential candidate genes upstream and downstream of the GWAS signal that might harbor risk/protective variants influencing fast beta EEG and related disorders. These genes include, but are not limited to, PDCD10, WDR49, SERPINI1, SERPINI2 and ZBBX. Given that there are two recombination hotspots between rs11720469 and BCHE, it is possible that BCHE is not directly involved in the association of 3q26 and fast beta EEG observed in this study. WDR49 has previously been associated with quantity of visceral fat91 and SERPINI1 has previously been associated with variation in heart rate.92
