Most notable is the relatively small sample size and related lack of statistical power to detect subtle genotypic effects. However, GWAS results seem reliable based on corroborating information (that is, several genome-wide significant SNPs in high LD, biological plausibility, replication in an independent sample). Furthermore, given the nominal associations observed in eQTL analyses, these findings must be replicated in larger samples of individuals of AA. Finally, future studies should examine the effects of genetic variants on trajectories of beta EEG during development in order to delineate age-specific effects and the links between these effects and/or the onset of psychopathology (AUD, ADHD, CoD).
