Additional validation of these results was recently obtained by our group while conducting miRNA microarray studies in a mouse model of highethanol consumption (unpublished data). Mouse homologs of 5 out of the 6 human miRNAs assessed by qRT-PCR (hsa-let-7g, hsa-miR-15b, hsa-miR-152, hsa-miR-7, and hsa-miR-301a) were also found significantly upregulated in the mouse microarray study. This conservation across species represents further invaluable validation of the role played by these miRNAs in alcohol-related cellular mechanisms.
