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Chunk #37 — Discussion — Limitations in Understanding the LFP, and their Solutions

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How local is the local field potential?
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because, as discussed above, the factors that impact LFP recordings, both physiological (e.g., strength, spatial extent and symmetry of activation in the neuronal substrate), and technical (e.g., electrode characteristics and reference site) have not been incorporated into the analysis. While an intracranial recording tends to be dominated by activity near the active electrode, all that can be said with certainty is that the generator of the LFP is generated somewhere in the conductive medium. Volume conduction effects are a major source of uncertainty in this arena, and several solutions to the problem are worth considering.