Chunk #29 — Results — Alcohol self-administration behavior: nondependent alcohol self-administration and excessive alcohol self-administration during alcohol dependence (termed henceforth as nondependent drinking and alcohol dependence)

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Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence.

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reliable blood alcohol levels: (dependent: (Set I: 193.2 ± 17.7 mg%; Set II: 159.7 ± 9.7 mg%; p = 0.14) versus nondependent: Set I and II combined, 10 ± 0.5 mg%, F = 227.6, p < 0.0001). Previous work shows the temporal profile of elevations in blood alcohol levels during self-administration sessions, in which nondependent animals rarely elevate blood alcohol levels above 50 mg%, where as dependent animals rapidly increase blood alcohol levels 2-3 fold that of nondependent animals (often reaching blood alcohol levels as high as 100-150 mg% during a 30 min session (Richardson et al., 2008).