Permanent impairment of birth and survival of cortical and hippocampal proliferating cells following excessive drinking during alcohol dependence.
paper
Cited
Public
- Authors
- Richardson, Heather N; Chan, Stephanie H; Crawford, Elena F; Lee, Youn Kyung; Funk, Cindy K; Koob, George F; Mandyam, Chitra D
- Year
- 2009
- Journal
- Neurobiology of disease
- PMID
- 19501165
- DOI
- 10.1016/j.nbd.2009.05.021
- PMCID
- PMC2742572
Experimenter-delivered alcohol decreases adult hippocampal neurogenesis and hippocampal-dependent learning and memory. The present study used clinically relevant rodent models of nondependent limited access alcohol self-administration and excessive drinking during alcohol dependence (alcohol self-administration followed by intermittent exposure to alcohol vapors over several weeks) to compare alcohol-induced effects on cortical gliogenesis and hippocampal neurogenesis. Alcohol dependence, but not nondependent drinking, reduced proliferation and survival in the medial prefrontal cortex (mPFC). Apoptosis was reduced in both alcohol groups within the mPFC, which may reflect an initiation of a reparative environment following alcohol exposure as decreased proliferation was abolished after prolonged dependence. Reduced proliferation, differentiation, and neurogenesis were observed in the hippocampus of both alcohol groups, and prolonged dependence worsened the effects. Increased hippocampal apoptosis and neuronal degeneration following alcohol exposure suggest a loss in neuronal turnover and indicate that the hippocampal neurogenic niche is highly vulnerable to alcohol.
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| Title | Authors | Journal | Year | Link |
|---|---|---|---|---|
| Abstinence and Fear Experienced during This Period Produce Distinct Cortical and Hippocampal Adaptations in Alcohol-Dependent Rats. | Steiner NL et al. | β | 2024 | β |
| Adolescent binge ethanol impacts H3K9me3-occupancy at synaptic genes and the regulation of oligodendrocyte development. | Brocato ER et al. | β | 2024 | β |
| Detrimental Effects of Alcohol-Induced Inflammation on Brain Health: From Neurogenesis to Neurodegeneration. | Anand SK et al. | β | 2023 | β |
| Evaluating signs of hippocampal neurotoxicity induced by a revisited paradigm of voluntary ethanol consumption in adult male and female Sprague-Dawley rats. | Colom-Rocha C et al. | β | 2023 | β |
| Progenitor Cells Play a Role in Reinstatement of Ethanol Seeking in Adult Male and Female Ethanol Dependent Rats. | Nonoguchi HA et al. | β | 2023 | β |
| 7,8-DHF enhances SHH in the hippocampus and striatum during early abstinence but has minor effects on alcohol intake in IA2BC paradigm and abstinence-related anxiety-like behavior in rats. | Peregud D et al. | β | 2022 | β |
| Cholinergic and Neuroimmune Signaling Interact to Impact Adult Hippocampal Neurogenesis and Alcohol Pathology Across Development. | Macht VA et al. | β | 2022 | β |
| Ethanol Induces Secretion of Proinflammatory Extracellular Vesicles That Inhibit Adult Hippocampal Neurogenesis Through G9a/GLP-Epigenetic Signaling. | Zou J et al. | β | 2022 | β |
| Abstinence from ethanol dependence produces concomitant cortical gray matter abnormalities, microstructural deficits and cognitive dysfunction. | Somkuwar SS et al. | β | 2021 | β |
| Alcohol drinking during early adolescence activates microglial cells and increases frontolimbic Interleukin-1 beta and Toll-like receptor 4 gene expression, with heightened sensitivity in male rats compared to females. | Silva-Gotay A et al. | β | 2021 | β |
| Chronic ethanol exposure differentially alters neuronal function in the medial prefrontal cortex and dentate gyrus. | Avchalumov Y et al. | β | 2021 | β |
| Expression of Oligodendrocyte and Oligoprogenitor Cell Proteins in Frontal Cortical White and Gray Matter: Impact of Adolescent Development and Ethanol Exposure. | Liu W et al. | β | 2021 | β |
| Functional Activation of Newborn Neurons Following Alcohol-Induced Reactive Neurogenesis. | Nawarawong NN et al. | β | 2021 | β |
| Isoxazole-9 reduces enhanced fear responses and retrieval in ethanol-dependent male rats. | Staples MC et al. | β | 2021 | β |
| Reactive, Adult Neurogenesis From Increased Neural Progenitor Cell Proliferation Following Alcohol Dependence in Female Rats. | Nawarawong NN et al. | β | 2021 | β |
| A Novel Sulfonamide, 4-FS, Reduces Ethanol Drinking and Physical Withdrawal Associated With Ethanol Dependence. | Sona Khan M et al. | β | 2020 | β |
| Brain-wide functional architecture remodeling by alcohol dependence and abstinence. | Kimbrough A et al. | β | 2020 | β |
| Chronic alcohol-induced liver injury correlates with memory deficits: Role for neuroinflammation. | King JA et al. | β | 2020 | β |
| Recovery of Hippocampal-Dependent Learning Despite Blunting Reactive Adult Neurogenesis After Alcohol Dependence. | Nickell CG et al. | β | 2020 | β |
| Role of Hippocampal Neurogenesis in Alcohol Withdrawal Seizures. | Basu S et al. | β | 2020 | β |
| Sex Differences in the Neurobiology of Alcohol Use Disorder. | Flores-Bonilla A et al. | β | 2020 | β |
| Tumour Necrosis Factor in Neuroplasticity, Neurogenesis and Alcohol Use Disorder. | Alvarez Cooper I et al. | β | 2020 | β |
| Dysregulation of c-Jun N-terminal kinase phosphorylation in alcohol dependence. | Pahng AR et al. | β | 2019 | β |
| Effects of Chronic Voluntary Alcohol Drinking on Thiamine Concentrations, Endoplasmic Reticulum Stress, and Oxidative Stress in the Brain of Crossed High Alcohol Preferring Mice. | Xu H et al. | β | 2019 | β |
| The P300 in alcohol use disorder: A meta-analysis and meta-regression. | Hamidovic A et al. | β | 2019 | β |
| Activation of neural stem cells from quiescence drives reactive hippocampal neurogenesis after alcohol dependence. | Hayes DM et al. | β | 2018 | β |
| Bone Marrow Derived Mesenchymal Stem Cells in Addiction Related Hippocampal Damages. | Rafaiee R et al. | β | 2018 | β |
| Ethanol Reinforcement Elicits Novel Response Inhibition Behavior in a Rat Model of Ethanol Dependence. | Somkuwar SS et al. | β | 2018 | β |
| Hippocampal neural progenitor cells play a distinct role in fear memory retrieval in male and female CIE rats. | Fannon MJ et al. | β | 2018 | β |
| Neurogenesis during Abstinence Is Necessary for Context-Driven Methamphetamine-Related Memory. | Galinato MH et al. | β | 2018 | β |
| Hyper-oligodendrogenesis at the vascular niche and reduced blood-brain barrier integrity in the prefrontal cortex during protracted abstinence. | Somkuwar SS et al. | β | 2017 | β |
| Platelet Endothelial Cell Adhesion Molecule-1 and Oligodendrogenesis: Significance in Alcohol Use Disorders. | Mandyam CD et al. | β | 2017 | β |
| The Prefrontal Cortex as a Critical Gate of Negative Affect and Motivation in Alcohol Use Disorder. | Pahng AR et al. | β | 2017 | β |
| Type 2 Neural Progenitor Cell Activation Drives Reactive Neurogenesis after Binge-Like Alcohol Exposure in Adolescent Male Rats. | Nickell CRG et al. | β | 2017 | β |
| Alcohol dependence-induced regulation of the proliferation and survival of adult brain progenitors is associated with altered BDNF-TrkB signaling. | Somkuwar SS et al. | β | 2016 | β |
| Chronic Drinking During Adolescence Predisposes the Adult Rat for Continued Heavy Drinking: Neurotrophin and Behavioral Adaptation after Long-Term, Continuous Ethanol Exposure. | Fernandez GM et al. | β | 2016 | β |
| Thinking after Drinking: Impaired Hippocampal-Dependent Cognition in Human Alcoholics and Animal Models of Alcohol Dependence. | Staples MC et al. | β | 2016 | β |
| Wheel running reduces ethanol seeking by increasing neuronal activation and reducing oligodendroglial/neuroinflammatory factors in the medial prefrontal cortex. | Somkuwar SS et al. | β | 2016 | β |
| Brain pathways to recovery from alcohol dependence. | Cui C et al. | β | 2015 | β |
| Divergent regulation of distinct glucocorticoid systems in alcohol dependence. | Edwards S et al. | β | 2015 | β |
| Interactions between chronic ethanol consumption and thiamine deficiency on neural plasticity, spatial memory, and cognitive flexibility. | Vedder LC et al. | β | 2015 | β |
| Protracted abstinence from chronic ethanol exposure alters the structure of neurons and expression of oligodendrocytes and myelin in the medial prefrontal cortex. | Navarro AI et al. | β | 2015 | β |
| Structural reorganization of pyramidal neurons in the medial prefrontal cortex of alcohol dependent rats is associated with altered glial plasticity. | Kim A et al. | β | 2015 | β |
| Alcohol and adult hippocampal neurogenesis: promiscuous drug, wanton effects. | Geil CR et al. | β | 2014 | β |
| Alcohol exposure inhibits adult neural stem cell proliferation. | Campbell JC et al. | β | 2014 | β |
| Ectopic hippocampal neurogenesis in adolescent male rats following alcohol dependence. | McClain JA et al. | β | 2014 | β |
| Long-term effects of peripubertal binge EtOH exposure on hippocampal microRNA expression in the rat. | Prins SA et al. | β | 2014 | β |
| Operant alcohol self-administration in dependent rats: focus on the vapor model. | Vendruscolo LF et al. | β | 2014 | β |
| Rodent models for compulsive alcohol intake. | Hopf FW et al. | β | 2014 | β |
| Role of NG2 expressing cells in addiction: a new approach for an old problem. | Somkuwar SS et al. | β | 2014 | β |
| ΞΌ-Opioid receptors mediate the effects of chronic ethanol binge drinking on the hippocampal neurogenic niche. | Contet C et al. | β | 2014 | β |
| Perinatal supplementation with omega-3 polyunsaturated fatty acids improves sevoflurane-induced neurodegeneration and memory impairment in neonatal rats. | Lei X et al. | β | 2013 | β |
| Stress-response pathways are altered in the hippocampus of chronic alcoholics. | McClintick JN et al. | β | 2013 | β |
| The Interplay between the Hippocampus and Amygdala in Regulating Aberrant Hippocampal Neurogenesis during Protracted Abstinence from Alcohol Dependence. | Mandyam CD | β | 2013 | β |
| Functional role of adult hippocampal neurogenesis as a therapeutic strategy for mental disorders. | Jun H et al. | β | 2012 | β |
| The addicted brain craves new neurons: putative role for adult-born progenitors in promoting recovery. | Mandyam CD et al. | β | 2012 | β |
| Hippocampal volume differences in Gulf War veterans with current versus lifetime posttraumatic stress disorder symptoms. | Apfel BA et al. | β | 2011 | β |
| Atrophy of the parahippocampal gyrus and regional cerebral blood flow in the limbic system in chronic alcoholic patients. | Suzuki Y et al. | β | 2010 | β |
| Long-lasting reduction in hippocampal neurogenesis by alcohol consumption in adolescent nonhuman primates. | Taffe MA et al. | β | 2010 | β |
| Long-term suppression of forebrain neurogenesis and loss of neuronal progenitor cells following prolonged alcohol dependence in rats. | Hansson AC et al. | β | 2010 | β |
| Roles of neural stem cells and adult neurogenesis in adolescent alcohol use disorders. | Nixon K et al. | β | 2010 | β |