A meta-analysis of prospective cohort studies reported an association between ischaemic stroke and a SNP in the 12p13 region, although this was not replicated in an independent study.13 The underlying gene was suggested to be NINJ2.12 This association was present in the METASTROKE discovery cohort, but this cohort contained the datasets in which the original association had been determined. When these datasets were excluded, there was no evidence of any associations.
