In a Japanese population, a variant in PRKCH has been associated with small-artery disease, a stroke subtype that is particularly common in this ethnic group.11 This association was confirmed in a prospective study with relatively few stroke endpoints, and also in a Chinese population.25, 26 Interestingly, an association was also suggested with cerebral haemorrhage, which shares some underlying pathological similarities with cerebral small-vessel disease causing lacunar infarction. The association has not yet been examined in other ancestral groups. The SNP is monomorphic in European populations and therefore we were unable to examine whether the association was present in our population. However, we assessed all SNPs at this chromosomal region and noted no evidence of any association in our population of European ancestry.
