The age-related changes in the regional nodal properties were predominately found in the frontal and parietal lobes. Age-related increases were found in several frontal brain regions (e.g., SFGmed.R, ORBmed.R, SMA.L, SMA.R, and MCG.R), which appear to be those of the last brain regions to mature and related to the increasing cognitive capacity during childhood [74]. Moreover, several key brain regions (e.g., PCG.L, SFGmed.R, and ORBmed.R) of the default mode network (DMN) [75], [76] showed age-related increases. These findings were consistent with evidence that the DMN is only sparsely connected (i.e., fragmented) and becomes significantly more integrated during development [70]. However, two of the key DMN regions (bilateral PCUN) showed a positive quadratic (e.g., U-shaped) developmental trajectory or a linear age-related decrease in the regional nodal properties. A previous study on the structural brain networks in healthy pediatric subjects during the first years of life indicated that the right precuneus shows a quite high value in the node betweenness among all brain regions [57]. In this study, the bilateral precuneus also showed high values in the regional node parameters (identified as
