first years of life indicated that the right precuneus shows a quite high value in the node betweenness among all brain regions [57]. In this study, the bilateral precuneus also showed high values in the regional node parameters (identified as a global hub) across all subjects. Thus, regarding the functional connectivity, we assumed that the bilateral precuneus was likely to be developed early, preserving the high values with a slight decrease during childhood. We also found several brain regions showing a linear age-related decrease (e.g., bilateral PCL, SPG.R, SFGdor.L, HES.R, HIP.R, and CAL.R) and a negative quadratic (e.g., inverted U-shape) developmental trajectory (e.g., SPG.L and PAL.L), which are primarily related to motor, somatosensory, auditory, and visual functions. Recent studies demonstrate that the global hubs in functional brain networks are largely confined to primary sensory and motor brain regions in the infant brain [56], [58]. However, the global hubs identified in the adult brain are mainly composed of heteromodal association cortices [51], as indicated by recent studies on structural [10], [37], [63], [64], [77], [78] and functional [52], [62] brain networks. Therefore, our results suggested that the frontal brain regions associated with the higher-order cognitive functions developed during childhood, whereas the
