The associations between CADM2 and risk behavior and indices of self‐control are shown in Table 2. Associations that were significant after FDR‐correction for multiple testing (at p < .05) are indicated with an asterisk. Both lifetime tobacco use and lifetime cannabis use were associated with CADM2 in the meta‐analyses. In the individual samples, these associations were significant in NTR and UKB but not in 25Up and S4S. No significant associations were found for lifetime use of other substances (i.e., recreational drugs), although it must be noted that this variable was not present in the largest sample (UKB). None of the age at initiation of substance use variables were associated with CADM2. The smallest p‐value was.049 in the NTR sample for age at alcohol initiation. After correction for multiple testing, this finding was no longer significant. The meta‐analyses revealed associations between both average alcohol consumption and average number of cigarettes per day and CADM2 that seem to be largely driven by significant associations in the UKB sample. Regular alcohol use, problematic alcohol use, regular tobacco use, and nicotine dependence were all
