both average alcohol consumption and average number of cigarettes per day and CADM2 that seem to be largely driven by significant associations in the UKB sample. Regular alcohol use, problematic alcohol use, regular tobacco use, and nicotine dependence were all associated with CADM2 in the meta‐analyses. In the individual study analyses, only regular alcohol use was after correction significantly associated with CADM2 in a sample (S4S) other than the UKB. The number of sexual partners was associated with CADM2 in 25Up, UKB and the meta‐analysis, and age at first sexual intercourse in UKB and the meta‐analysis but not in the individual 25Up, S4S, or NTR samples.
