a private institutional review board. The sample included 55.3% females and the age ranged between 18 and 94 years with a mean of 54.0 years. Within the sample, 43.2% had used cannabis during their lifetime. The third sample was obtained from UK-Biobank. Data were available for 126,785 individuals of European ancestry. The sample included 56.3% females and the age ranged between 39 and 72 years with a mean of 55.0 years. Within the sample, 22.3% had used cannabis during their lifetime. Ethical approval for UK-Biobank data collection procedures has been provided by the North West Multi-centre Research Ethics Committee (MREC), the National Information Governance Board for Health & Social Care (NIGB), and the Community Health Index Advisory Group (CHIAG).
