Data from three sources were obtained: ICC, 23andMe, and UK-Biobank (total N=184,765). We used existing GWAS summary statistics from the ICC, based on data from 35,297 individuals of European ancestry from 16 cohorts from Northern America, Europe, and Australia10. Details regarding ethical approval and informed consents of the ICC cohorts can be found in the supplementary material of the original ICC paper10. The overall sample included 55.5% females and the age ranged between 16 and 87 years with a mean of 35.7 years. An average of 42.8% of the individuals had used cannabis during their lifetime. The second set of results was derived from the personal genetics company 23andMe Inc.. Data were available for 22,683 individuals of European Ancestry who provided informed consent and answered surveys online according to a human subjects protocol approved by Ethical & Independent Review Services, a private institutional review board. The sample included 55.3% females and the age ranged between 18 and 94 years with a mean of 54.0 years. Within the sample, 43.2% had used cannabis during their lifetime. The third sample was obtained
