Chunk #32 — Methods — Content targeted for coverage — Addiction-related genes

Source: Smokescreen: a targeted genotyping array for addiction research.
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One thousand fourteen genes were identified as related to addiction through expert nomination, and recent bioinformatics projects and knowledge-bases. Table 4 presents the source, annotation, and gene count. Sources include the NIDA Genetics Consortium [76, 77], Gene Ontology [78], QIAGEN’s Ingenuity Pathway Analysis [79], and Pharmacogenetics of Nicotine Addiction Treatment [31, 37].Table 4Smokescreen addiction genes: source, categories, and counts*SourceCategoryGenesGene Ontologydopamine_receptor_binding8Gene Ontologydopamine_binding9Gene Ontologyserotonin_uptake4Gene Ontologyserotonin_metabolic_process8Gene Ontologyserotonin_transport12Gene Ontologyresponse_to_nicotine31Gene Ontologydopamine_secretion15Gene Ontologydopamine_uptake8Gene Ontologydopamine_receptor_signaling_pathway30Gene Ontologydopamine_transport23Gene Ontologyserotonin_secretion8Gene Ontologydopamine_metabolic_process26Gene Ontologyregulation_of_dopamine_secretion15IPAcigarette_habituation_susceptibility_syndrome6IPAnicotine14IPAsusceptibility_to_drug_addiction1IPAaddiction_behavior24IPAtobacco27IPAaddiction131IPAwithdrawal11IPAsmoking12IPAnaltrexone4IPAclonidine7IPAnortripyline3IPAvarenicline3IPAnicotine19IPAbupropion3NIDA Genetics ConsortiumThe Nicotine System20NIDA Genetics ConsortiumThe Dopamine System10NIDA Genetics ConsortiumMouse QTL423NIDA Genetics ConsortiumThe Alcohol System32NIDA Genetics ConsortiumThe Cholinergic System9NIDA Genetics ConsortiumThe Adrenergic System16NIDA Genetics ConsortiumTyrosine3NIDA Genetics ConsortiumOther263NIDA Genetics ConsortiumThe GABA System31NIDA Genetics ConsortiumNeurotransmitter Transporters13NIDA Genetics ConsortiumThe Nicotine Metabolism System11NIDA Genetics ConsortiumThe Serotonergic System20NIDA Genetics ConsortiumThe Endocannabinoid System2NIDA Genetics ConsortiumDopamine Synthesis2NIDA Genetics ConsortiumThe Glutamatergic System42NIDA Genetics ConsortiumThe Opioid System12PNAT134*Genes in categories may overlap