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Chunk #31 — Methods — Content targeted for coverage — Genome-wide association markers

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Smokescreen: a targeted genotyping array for addiction research.
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A catalog panel was provided by Affymetrix to provide baseline genome-wide coverage across AFR, ASN, and EUR ancestry groups for discovery as well as meta-analysis across studies. 246,038 of the catalog markers overlap with the Affymetrix Axiom Biobank array. We included an additional panel of 50,000 markers provided by Affymetrix to increase genome-wide coverage in African ancestry populations, thereby maximizing genotype imputation efficiency to a larger variant set [74, 75].