White matter deficits have been noted for some time in individuals with a history of prenatal alcohol exposure, and Wozniak and Muetzel pursue this finding with a review of the microstructural integrity of white matter using diffusion tensor imaging (DTI). Again, the history of this method in research on FASD is relatively brief, but several studies have identified abnormalities in white matter integrity, especially in the corpus callosum, a structure affected by prenatal alcohol exposure (see Lebel et al. this volume). Recent whole brain DTI studies have reported widespread disruption of integrity and, importantly, relationships between white matter integrity and behavior have been noted. Of interest, the authors consider the findings in FASD with those of other disorders.
