We also investigated replication of previously-described BP loci in GERA (Supplementary Table 6, which also reports the GERA lead SNP when it differs from the previously-described lead SNP at the locus)4–22. For the 85 previously-described lead SNPs (or an r2=1.00 proxy for one SNP), 62.4% (53/85) were significantly associated with at least one GERA BP phenotype at P<0.00059 (Bonferroni adjustment for 85 tests) and had the same direction of effect; 78.8% (67/85) were nominally significant; 95.3% (81/85) had effects in the same direction. Replication was stronger in UKB, with 77.6% (66/85) replicating at Bonferroni significance, 89.4% (76/85) at nominal significance, and 96.5% (82/85) in the same direction. The replication was further improved in meta-analysis of GERA and UKB, where 84.7% (72/85) met Bonferroni significance, 89.4% (76/85) were nominally significant, and 96.5% (82/85) had effects in the same direction.
