In addition, testing an aggregate, weighted genetic risk score (GRS) using all 85 previously-described SNPs for each BP trait led to highly significant associations in all GERA groups with P<10−168 (whites), P<10−22 (Latinos), P<10−9 (East Asians), and P<0.002 (African Americans), and P<10−350 in UKB whites, for all BP traits, (Table 3). In GERA, Latinos had a larger mean SBP GRS than whites (P=0.053), while African Americans had a lower one (P=0.032). When GERA African Americans were stratified by European ancestry, SBP GRS were lower in individuals with 0%-50% European ancestry (coefficient=0.65, 95% CI=0.18-1.13) than in those with 50%-100% European ancestry (coefficient=1.04, 95% CI=0.56-1.51), although these confidence intervals overlap. The same trend appeared for DBP and PP (Table 3). There was also a very high degree of concordance of the estimated regression coefficients for SBP, DBP, and PP among the non-Hispanic whites in GERA, ICBP, and the UKB (Supplementary Figure 7).
